Titration Calculator
Build a week-by-week dose escalation schedule with exact calendar dates. Enter your start and target dose, set the pace, and get a personalized timeline.
What is peptide titration?
Titration means starting at a low dose and incrementally increasing it over weeks until you reach the therapeutic target. The purpose is straightforward: it lets your body adapt gradually so side effects stay manageable.
Syntho protocols use a 3-phase model: a ramp-up period at reduced dose, the main phase at full therapeutic dose, and a taper before the off-cycle. GLP-1 peptides like semaglutide and tirzepatide use a multi-step escalation instead, climbing through defined dose levels over 16-24 weeks.
The presets in this calculator match the exact protocols used in Syntho-generated protocols. The custom builder lets you plan the same 3-phase structure for any peptide.
Standard titration protocols
Reference schedules for common peptides. Each follows published dosing guidelines. Expand any protocol to see the phase breakdown and practical notes.
Managing side effects during escalation
Mild nausea at each dose increase is expected and usually fades within 1-2 weeks. These strategies help minimize discomfort during the transition.
Stay hydrated
64 oz of water minimum daily. Dehydration amplifies nausea and constipation, both common during dose increases.
Smaller meals, more often
GLP-1 peptides slow gastric emptying. Large meals sit longer and feel worse. Smaller portions spread across the day work better.
Avoid high-fat foods during ramps
Fatty foods take the longest to digest. During the first 1-2 weeks at each new dose, lean protein and simple carbs are easier on the stomach.
Inject in the evening
Peak side effects hit a few hours after injection. Evening dosing means the worst passes while you sleep.
Rotate injection sites
Alternate between abdomen, thigh, and upper arm. Repeated injections in the same spot can cause local irritation and lipodystrophy.
Know when to extend a phase
If nausea has not improved after 2 weeks at a dose, stay at that level for another 1-2 weeks before moving up. This is normal, not a failure.
When to contact a provider. Persistent vomiting beyond 3 days, severe abdominal pain, inability to keep fluids down, or signs of allergic reaction (rash, swelling, difficulty breathing) warrant immediate medical attention. These are not normal titration side effects.
Common questions
Dose escalation timing, safety, and how the schedule works.